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Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-╬▓ in Hepatocellular Carcinoma

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri.

Abstract
Hepatocellular carcinoma is one of the most common malignant tumor and leading cause of death worldwide. Tumor genes, signals from tumor stroma, recruited inflammatory cells and hypoxia has been reported to switch on angiogenesis. Vascular endothelial growth factor is a pleiotropic factor that regulates cell proliferation, vascular permeability and plays an important role in tumor angiogenesis through its different angiogenic receptors. Multifunctional regulatory cytokine transforming growth factor-╬▓ also controls cell proliferation, differentiation, extracellular matrix production and survival/or apoptosis of many types cells. By raising level of epithelialľmesenchymal transition, transforming growth factor-╬▓ creates a favourable microenvironment for tumor cell growth. Depending upon the stage of cancer progression it can either initiate tumor development, progression and metastasis or can act as a tumor suppressor. In the present review, an attempt has been made to comprehensively define the role of Vascular Endothelial Growth Factor and transforming growth factor-╬▓ in the development and progression of hepatocellular carcinoma.

Key words: Hepatocellular carcinoma; VEGF; TGF-╬▓; angiogenesis; cancer


 
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How to Cite this Article
Pubmed Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309



Web Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. www.scopemed.org/?mno=268878 [Access: November 24, 2017]. doi:10.5455/umj.20170608022309



AMA (American Medical Association) Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309



Vancouver/ICMJE Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. (2017), [cited November 24, 2017]; 3(2): 25-31. doi:10.5455/umj.20170608022309



Harvard Style

Chhonker, S. K., Rawat, D. & Koiri, R. K. (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J, 3 (2), 25-31. doi:10.5455/umj.20170608022309



Turabian Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. 2017. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309



Chicago Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3 (2017), 25-31. doi:10.5455/umj.20170608022309



MLA (The Modern Language Association) Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3.2 (2017), 25-31. Print. doi:10.5455/umj.20170608022309



APA (American Psychological Association) Style

Chhonker, S. K., Rawat, D. & Koiri, R. K. (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309








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The articles in Ulutas Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.