E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease

Serdar Dogan, Hamza Malik Okuyan, Gul Ilhan.

Abstract
Introduction: Sickle cell disease (SCD) is a prevalent monogenic hemoglobin disorder that presents a global burden with life-threatening complications. More studies are needed to understand the complex pathophysiology that causes multi-organ damage and develop effective approaches that ameliorate the clinical complications of patients with SCD. In the present study, we aimed to explore the relationship of Kallistatin with VEGF-A and TNF-α in patients with SCD.
Materials and methods: Thirty patients with SCD and 28 age- and sex-matched healthy subjects were included in the study. Serum Kallistatin, VEGF-A and TNF-α levels were measured by Enzyme-Linked Absorbent Assay (ELISA) and biochemical parameters were analyzed with routine techniques.
Results: The levels of Kallistatin, VEGF-A, leukocyte, AST, ALT, total bilirubin, direct bilirubin, LDH, and CRP were significantly higher in the patient group than in the control group whereas RBC and hemoglobin levels were significantly lower in patients than healthy individuals. Kallistatin levels were positively correlated with AST, total bilirubin, direct bilirubin, LDH, CRP, VEGF-A. VEGF-A levels were positively correlated with WBC, ALT, total bilirubin, while VEGF-A negatively correlated with RBC and hemoglobin. The areas under the receiver operating characteristic for Kallistatin and VEGF-A were 0.8536 and 0.7488, respectively.
Conclusion: We report for the first time that Kallistatin could be a novel marker associated with the pathogenesis of SCD.

Key words: Kallistatin, VEGF-A, Sickle Cell Disease, Angiogenesis


 
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How to Cite this Article
Pubmed Style

Dogan S, Okuyan HM, Ilhan G. Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. Ulutas Med J. 2021; 7(4): 220-227. doi:10.5455/umj.20211101020302


Web Style

Dogan S, Okuyan HM, Ilhan G. Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. https://www.ulutasmedicaljournal.com/?mno=137221 [Access: June 14, 2022]. doi:10.5455/umj.20211101020302


AMA (American Medical Association) Style

Dogan S, Okuyan HM, Ilhan G. Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. Ulutas Med J. 2021; 7(4): 220-227. doi:10.5455/umj.20211101020302



Vancouver/ICMJE Style

Dogan S, Okuyan HM, Ilhan G. Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. Ulutas Med J. (2021), [cited June 14, 2022]; 7(4): 220-227. doi:10.5455/umj.20211101020302



Harvard Style

Dogan, S., Okuyan, . H. M. & Ilhan, . G. (2021) Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. Ulutas Med J, 7 (4), 220-227. doi:10.5455/umj.20211101020302



Turabian Style

Dogan, Serdar, Hamza Malik Okuyan, and Gul Ilhan. 2021. Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. THE ULUTAS MEDICAL JOURNAL, 7 (4), 220-227. doi:10.5455/umj.20211101020302



Chicago Style

Dogan, Serdar, Hamza Malik Okuyan, and Gul Ilhan. "Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease." THE ULUTAS MEDICAL JOURNAL 7 (2021), 220-227. doi:10.5455/umj.20211101020302



MLA (The Modern Language Association) Style

Dogan, Serdar, Hamza Malik Okuyan, and Gul Ilhan. "Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease." THE ULUTAS MEDICAL JOURNAL 7.4 (2021), 220-227. Print. doi:10.5455/umj.20211101020302



APA (American Psychological Association) Style

Dogan, S., Okuyan, . H. M. & Ilhan, . G. (2021) Serum Kallistatin Levels are Associated with the Pathogenesis of Sickle Cell Disease. THE ULUTAS MEDICAL JOURNAL, 7 (4), 220-227. doi:10.5455/umj.20211101020302