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Determining Hepatitis C virus genotype distribution of Amasya area

Cetin Kilinc, Ridvan Guckan, Onder Idil, Yuksel Guleryuzlu, Mustafa Capraz, Kemal Turker Ulutas.

Cited by (1)

Abstract
Hepatitis C virus (HCV) is one of the most common reasons for liver carcinoma, cirrhosis and chronic liver deficiency worldwide. Knowing the genotype of HCV with many genotypes before the treatment would be clinically useful in organizing the treatment and follow-up. Retrospective investigation of HCV genotypes in chronic hepatitis C patients applying to our hospital was aimed in our study. Results of 82 chronic hepatitis C patients sent to Amasya University Sabuncuoglu Serefeddin Education and Research Hospital Microbiology Laboratory between 2010-2014 with positive anti-HCV and HCV-RNA were included in our study. Viral genotyping was made using Qiagen one-step RT-PCR (Qiagen, Hilden, Germany) and ABI PRISM 3730 (Perkin Elmer, USA) systems in order using real-time polymerase chain reaction (Rt-PCR) method. 79 (96.34%) of the patients were genotype 1, 2 (2.42%) were genotype 2 and 1 was (1.21%) genotype 3. The most common sub-types were found genotype 1b (69.51%) and genotype 1a (20.73%) in order.
HCV genotype 1 (96.34%) is seen in high ratios in our area and the most common sub type is genotype 1b (69.51%).

Key words: Hepatitis C virus, chronic hepatitis, genotype


 
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REFERENCES
1. Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alpha- 2b plus ribavirin compared with interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-65. [DOI via Crossref]   
2. Koff RS. Hepatitis C. In: Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious Diseases. 3rd ed. Philadelphia: Lippincott Williams, 2004: 779-784.
3. Nurdan Tozun, Osman C. Ozdogan, Yilmaz Cakaloglu, Ramazan Idilman, Zeki Karasu, Ulus S. Akarca,et al. A Nationwide prevalence study and risk factors for hepatitis A, B, C and D infections in Turkey. Hepatology. 2010; 52(1); 697.
4. Dincer D. Hepatit C Epidemiyolojisi ve Patogenezi. Turkiye Klinikleri Gastroenterohepatol Topics. 2010; 3(1): 77-80.
5. Nakano I, Fukuda Y, Katano Y, et al. Interferon responsiveness in patients infected with hepatitis C virus 1b differs depending on viral subtype. Gut 2001; 49: 263-7. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
6. Ural O, Arslan U, Fýndýk D. Konya bölgesinde hepatit C virusu genotip daðýlýmý. Ýnfeksiyon Derg 2007; 21: 175-81.
7. Türkoðlu S. Hepatit C virüsü: Viroloji ve seroloji. Viral Hepatit 2003. Viral Hepatitle Savaþ›m Derneði 2003; 186-98.
9. Thomas DL, Lemon SM. Hepatitis C. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases, 5th ed. Philadelphia: Churchill Livingstone Determination of hepatitis C virus genotype; 2000: p.1736.1760.
10. Sherlock S, Dooley J. Hepatitis C Virus. Diseases of the Liver and Biliary System. 11th edition 2002; 305-316.
11. Jimenez-Mendez R, Uribe-Salas F, López-Guillen P, Cisneros-Garza L, Casta-eda-Hernandez G. Distribution of HCV genotypes and HCV RNA viral load in different regions of Mexico. Ann Hepatol 2010; 9(1): 33-9. [Pubmed]   
12. Ramalho F, Costa A, Pires A et al: Correlation of genotypes and route of transmission with histologic activity and disease stage in chronic hepatitis C. Dig Dis Sci 2000,45:182-187. [DOI via Crossref]    [Pubmed]   
13. Altuðlu I, Sertöz R, Aksoy A, Gürsel D, Tüzüner U, Günþar F. Possible transmission risks and genotype distribution of hepatitis C virus infection in Western Turkey. Turk J Gastroenterol 2013; 24(5): 349-55.
14. Buruk CK, Bayramoðlu G, Reis A, Kaklýkkaya N, Tosun I, Aydýn F. Determination of hepatitis C virus genotypes among hepatitis C patients in Eastern Black Sea region, Turkey. Mikrobiyol Bul 2013; 47(4): 650-7. [DOI via Crossref]    [Pubmed]   
15. Saðlýk Ý, Mutlu D, Öngüt G, Ýnan D, Öðünç D, Distribution of Hepatitis C Virus Genotypes among Patients with Chronic Hepatitis C Infection in Akdeniz University Hospital, Antalya, Turkey: A Five-Year Evaluation Mikrobiyol Bul 2014; 48(3): 429-437 [DOI via Crossref]   
16. Kayman T, Karakükçü Ç, Karaman A, Gözütok F. Kayseri bölgesinde hepatit C virus enfeksiyonunun genotip daðýlýmý.Türk Mikrobiyol Cem Derg 2012; 42(1): 21-6.
17. Tezcan S, Ulger M, Aslan G, et al. Determination of hepatitis C virus genotype distribution in Mersin province, Turkey. Mikrobiyol Bul 2013; 47(2): 332-8. [DOI via Crossref]    [Pubmed]   
18. Noorali S, Pace DG, Bagasra O. Of lives and livers: emerging responses to the hepatitis C virus. J Infect Dev Ctries 2011; 5(1): 1-17. [Pubmed]   

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How to Cite this Article
Pubmed Style

Kilinc C, Guckan R, Idil O, Guleryuzlu Y, Capraz M, Ulutas KT. Determining Hepatitis C virus genotype distribution of Amasya area. Ulutas Med J. 2015; 1(2): 41-43. doi:10.5455/umj.20150528125725



Web Style

Kilinc C, Guckan R, Idil O, Guleryuzlu Y, Capraz M, Ulutas KT. Determining Hepatitis C virus genotype distribution of Amasya area. www.scopemed.org/?mno=189685 [Access: November 24, 2017]. doi:10.5455/umj.20150528125725



AMA (American Medical Association) Style

Kilinc C, Guckan R, Idil O, Guleryuzlu Y, Capraz M, Ulutas KT. Determining Hepatitis C virus genotype distribution of Amasya area. Ulutas Med J. 2015; 1(2): 41-43. doi:10.5455/umj.20150528125725



Vancouver/ICMJE Style

Kilinc C, Guckan R, Idil O, Guleryuzlu Y, Capraz M, Ulutas KT. Determining Hepatitis C virus genotype distribution of Amasya area. Ulutas Med J. (2015), [cited November 24, 2017]; 1(2): 41-43. doi:10.5455/umj.20150528125725



Harvard Style

Kilinc, C., Guckan, R., Idil, O., Guleryuzlu, Y., Capraz, M. & Ulutas, K. T. (2015) Determining Hepatitis C virus genotype distribution of Amasya area. Ulutas Med J, 1 (2), 41-43. doi:10.5455/umj.20150528125725



Turabian Style

Kilinc, Cetin, Ridvan Guckan, Onder Idil, Yuksel Guleryuzlu, Mustafa Capraz, and Kemal Turker Ulutas. 2015. Determining Hepatitis C virus genotype distribution of Amasya area. THE ULUTAS MEDICAL JOURNAL, 1 (2), 41-43. doi:10.5455/umj.20150528125725



Chicago Style

Kilinc, Cetin, Ridvan Guckan, Onder Idil, Yuksel Guleryuzlu, Mustafa Capraz, and Kemal Turker Ulutas. "Determining Hepatitis C virus genotype distribution of Amasya area." THE ULUTAS MEDICAL JOURNAL 1 (2015), 41-43. doi:10.5455/umj.20150528125725



MLA (The Modern Language Association) Style

Kilinc, Cetin, Ridvan Guckan, Onder Idil, Yuksel Guleryuzlu, Mustafa Capraz, and Kemal Turker Ulutas. "Determining Hepatitis C virus genotype distribution of Amasya area." THE ULUTAS MEDICAL JOURNAL 1.2 (2015), 41-43. Print. doi:10.5455/umj.20150528125725



APA (American Psychological Association) Style

Kilinc, C., Guckan, R., Idil, O., Guleryuzlu, Y., Capraz, M. & Ulutas, K. T. (2015) Determining Hepatitis C virus genotype distribution of Amasya area. THE ULUTAS MEDICAL JOURNAL, 1 (2), 41-43. doi:10.5455/umj.20150528125725








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