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Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility

Papitha P Anand, Vijaya Anand Arumugam, Chandra R Samuel.

Abstract
Background: Methylenetetrahydrofolate reductase is an important enzyme which plays a major role in folate metabolism and DNA methylation. The objective of this study was to analyze the MTHFR C677T polymorphism in infertile men.
Study Design: Blood samples were collected from 58 infertile men and 55 control subjects were taken which are fertile. C677T mutation analysis was done by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Method.
Results: The present study reveals that 23 Homozygous CC, 28 heterozygous CT, 7 TT were found in infertile men, whereas in control, the allele variations were 38 Homozygous CC, 17 heterozygous CT, but no Homozygous TT was found.
Conclusion: As a result, Genotypes and allele frequencies found in infertile patients and controls but mutant allele was found only in infertile men. Homozygous TT was observed only in azoospermia infertile men whereas heterozygous CT was found in both oligozoospermia and azoospermia subjects. The study has to be extended with a large number of samples.

Key words: Male infertility, MTHFR C677T, Folate, Homocysteine, Azoospermia


 
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Pubmed Style

Anand PP, Arumugam VA, Samuel CR. Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. Ulutas Med J. 2017; 3(1): 1-4. doi:10.5455/umj.20170402052343



Web Style

Anand PP, Arumugam VA, Samuel CR. Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. www.scopemed.org/?mno=262966 [Access: September 25, 2017]. doi:10.5455/umj.20170402052343



AMA (American Medical Association) Style

Anand PP, Arumugam VA, Samuel CR. Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. Ulutas Med J. 2017; 3(1): 1-4. doi:10.5455/umj.20170402052343



Vancouver/ICMJE Style

Anand PP, Arumugam VA, Samuel CR. Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. Ulutas Med J. (2017), [cited September 25, 2017]; 3(1): 1-4. doi:10.5455/umj.20170402052343



Harvard Style

Anand, P. P., Arumugam, V. A. & Samuel, C. R. (2017) Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. Ulutas Med J, 3 (1), 1-4. doi:10.5455/umj.20170402052343



Turabian Style

Anand, Papitha P, Vijaya Anand Arumugam, and Chandra R Samuel. 2017. Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. THE ULUTAS MEDICAL JOURNAL, 3 (1), 1-4. doi:10.5455/umj.20170402052343



Chicago Style

Anand, Papitha P, Vijaya Anand Arumugam, and Chandra R Samuel. "Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility." THE ULUTAS MEDICAL JOURNAL 3 (2017), 1-4. doi:10.5455/umj.20170402052343



MLA (The Modern Language Association) Style

Anand, Papitha P, Vijaya Anand Arumugam, and Chandra R Samuel. "Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility." THE ULUTAS MEDICAL JOURNAL 3.1 (2017), 1-4. Print. doi:10.5455/umj.20170402052343



APA (American Psychological Association) Style

Anand, P. P., Arumugam, V. A. & Samuel, C. R. (2017) Methylene Tetrahydrofolate Reductase C677T Gene Polymorphism In Male Infertility. THE ULUTAS MEDICAL JOURNAL, 3 (1), 1-4. doi:10.5455/umj.20170402052343








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