E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study

Hilmi Yetkin, Hilmi Demirkiran.

Abstract
Introduction: Intrathecal morphine is used to prevent post-dural puncture headache (PDPH). We aimed to investigate the effect of administering different doses of morphine intrathecally on PDPH in whom a cesarean section (CS) was performed under spinal anesthesia.
Materials and Methods: 80 ASA I-II pregnant women were included in the study. They were randomly divided into four groups: F25: 2ml of hyperbaric bupivacaine+25g of fentanyl intrathecally, M100: 2ml of hyperbaric bupivacaine +100g of morphine intrathecally, M150: 2ml of hyperbaric bupivacaine+150g of morphine intrathecally and M200: 2ml of hyperbaric bupivacaine+200g of morphine intrathecally. The patients were monitored for postoperative headache, development of PDPH, the requirement for epidural blood patch (EBP), the EBP number, the duration of hospitalization, and side effects that might occur within the first 24 hours (drug allergy, nausea, vomiting, itching, apnea, desaturation). All patients were assessed using the visual analog scale (VAS) for seven days postoperatively.
Results: The lowest rate of PDPD was determined in the M200. The highest VAS score of M200 was significantly lower than the other groups (p<0.05). The nausea-vomiting and itching rates were significantly lower in M100, M150, and M200.
Conclusion: PDPH rate was significantly low in the group that 200 g of morphine was administered. In the groups in which morphine was administered, the incidence of side effects was significantly higher than the group which administered fentanyl dose-independently.

Key words: Spinal anesthesia, cesarean section, postdural puncture headache, intrathecal morphine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Hilmi Yetkin
Articles by Hilmi Demirkiran
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Yetkin H, Demirkiran H. The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. Ulutas Med J. 2021; 7(1): 38-45. doi:10.5455/umj.20210203101035


Web Style

Yetkin H, Demirkiran H. The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. http://www.ulutasmedicaljournal.com/?mno=52030 [Access: March 29, 2021]. doi:10.5455/umj.20210203101035


AMA (American Medical Association) Style

Yetkin H, Demirkiran H. The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. Ulutas Med J. 2021; 7(1): 38-45. doi:10.5455/umj.20210203101035



Vancouver/ICMJE Style

Yetkin H, Demirkiran H. The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. Ulutas Med J. (2021), [cited March 29, 2021]; 7(1): 38-45. doi:10.5455/umj.20210203101035



Harvard Style

Yetkin, H. & Demirkiran, . H. (2021) The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. Ulutas Med J, 7 (1), 38-45. doi:10.5455/umj.20210203101035



Turabian Style

Yetkin, Hilmi, and Hilmi Demirkiran. 2021. The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. THE ULUTAS MEDICAL JOURNAL, 7 (1), 38-45. doi:10.5455/umj.20210203101035



Chicago Style

Yetkin, Hilmi, and Hilmi Demirkiran. "The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study." THE ULUTAS MEDICAL JOURNAL 7 (2021), 38-45. doi:10.5455/umj.20210203101035



MLA (The Modern Language Association) Style

Yetkin, Hilmi, and Hilmi Demirkiran. "The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study." THE ULUTAS MEDICAL JOURNAL 7.1 (2021), 38-45. Print. doi:10.5455/umj.20210203101035



APA (American Psychological Association) Style

Yetkin, H. & Demirkiran, . H. (2021) The Effect of Intrathecal Administration of Different Doses of Morphine on Headache after Dural Puncture in Cesarean Sections Under Spinal Anesthesia: A Randomized Double-Blind Controlled Study. THE ULUTAS MEDICAL JOURNAL, 7 (1), 38-45. doi:10.5455/umj.20210203101035