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Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review

Duane Bates, Jenny Edwards, Justin Chow, Michael Fisher, Aaron Switzer, Christine Morris.

Abstract
Background: Movement disorders are a very rare adverse effect of fluoroquinolones. The mechanism involves inhibition of GABA-A-receptors as well as activation of the excitatory NMDA receptors. This is thought to induce a hyperexcitable neuronal state. A literature review suggests this is a class effect and occurs shortly after initiation and resolves within a few days of discontinuation.
Case Presentation: A 62-year-old man with Campylobacter jejuni was treated with levofloxacin. The patient had normal liver enzymes and serum creatinine. Two hours after the initial dose of levofloxacin it was noted that the patient neck would shake and turn to the left and his right arm would abduct at the shoulder and flex at the elbow. The movements would occur every 1 to 2 minutes. There was muscle fasciculations in the bicep and forearm of the right arm briefly after the neck movement. The patient was given diphenhydramine 25 mg IV x 1 dose and within 20 minutes there was a reduction in the abnormal movements. Within 24 hours the movement disorder had completely resolved.
Conclusion: The case presented and literature review summarizes the data on fluoroquinolone induced movement disorders.

Key words: Fluoroquinolone, levofloxacin, movement disorder, motor dysfunction


 
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How to Cite this Article
Pubmed Style

Bates D, Edwards J, Chow J, Fisher M, Switzer A, Morris C. Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. Ulutas Med J. 2018; 4(1): 53-63. doi:10.5455/umj.20180207122003


Web Style

Bates D, Edwards J, Chow J, Fisher M, Switzer A, Morris C. Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. http://www.ulutasmedicaljournal.com/?mno=257886 [Access: September 26, 2018]. doi:10.5455/umj.20180207122003


AMA (American Medical Association) Style

Bates D, Edwards J, Chow J, Fisher M, Switzer A, Morris C. Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. Ulutas Med J. 2018; 4(1): 53-63. doi:10.5455/umj.20180207122003



Vancouver/ICMJE Style

Bates D, Edwards J, Chow J, Fisher M, Switzer A, Morris C. Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. Ulutas Med J. (2018), [cited September 26, 2018]; 4(1): 53-63. doi:10.5455/umj.20180207122003



Harvard Style

Bates, D., Edwards, J., Chow, J., Fisher, M., Switzer, A. & Morris, C. (2018) Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. Ulutas Med J, 4 (1), 53-63. doi:10.5455/umj.20180207122003



Turabian Style

Bates, Duane, Jenny Edwards, Justin Chow, Michael Fisher, Aaron Switzer, and Christine Morris. 2018. Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. THE ULUTAS MEDICAL JOURNAL, 4 (1), 53-63. doi:10.5455/umj.20180207122003



Chicago Style

Bates, Duane, Jenny Edwards, Justin Chow, Michael Fisher, Aaron Switzer, and Christine Morris. "Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review." THE ULUTAS MEDICAL JOURNAL 4 (2018), 53-63. doi:10.5455/umj.20180207122003



MLA (The Modern Language Association) Style

Bates, Duane, Jenny Edwards, Justin Chow, Michael Fisher, Aaron Switzer, and Christine Morris. "Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review." THE ULUTAS MEDICAL JOURNAL 4.1 (2018), 53-63. Print. doi:10.5455/umj.20180207122003



APA (American Psychological Association) Style

Bates, D., Edwards, J., Chow, J., Fisher, M., Switzer, A. & Morris, C. (2018) Fluoroquinolone Induced Movement Disorders: Case Report and Literature Review. THE ULUTAS MEDICAL JOURNAL, 4 (1), 53-63. doi:10.5455/umj.20180207122003








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