E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?

Nur Dokuzeylul Gunor, Tugba Gurbuz, Arzu Yurci.

Abstract
Introduction: The study investigated whether Gonadotropin-releasing hormone analog (GnRH-a) suppression before elective frozen-thawed embryo transfer (FET) allows better ongoing pregnancy rates (OPR) in women without endometriosis.
Material and methods: Retrospective cohort study including FET cycles performed in one academic fertility center from 2014 October to 2019 December. In the analog suppression group (ASG), depot analog was given on day 2 or 3, and estradiol (E2) treatment was started on the 21st day of analog usage. Intramuscular progesterone (100 mg/d) was added to E2 till the fetal heartbeat was seen. Then vaginal progesterone (600 mg/d) was continued until the 12th week of gestation.
Results: Among 523 FET, 22.4% underwent analog suppression, 77.6% had not undergone analog suppression before FET. There was no difference between groups concerning endometrial thickness, the number of embryos transferred, development of embryo stage at FET cycle, and cryopreservation technique. Implantation rate and ongoing pregnancy rates were significantly higher in the ASG than in the non-analog suppression group (NASG).
Conclusion: The use of GnRH-a before FET increases implantation rate and ongoing pregnancy rate not only in endometriosis cases but also in other patients with different infertility causes.

Key words: Analog suppression, assisted reproductive technology (ART), frozen-thawed embryo transfer


 
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How to Cite this Article
Pubmed Style

Gunor ND, Gurbuz T, Yurci A. Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. Ulutas Med J. 2021; 7(1): 22-30. doi:10.5455/umj.20210305041537


Web Style

Gunor ND, Gurbuz T, Yurci A. Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. http://www.ulutasmedicaljournal.com/?mno=61485 [Access: March 29, 2021]. doi:10.5455/umj.20210305041537


AMA (American Medical Association) Style

Gunor ND, Gurbuz T, Yurci A. Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. Ulutas Med J. 2021; 7(1): 22-30. doi:10.5455/umj.20210305041537



Vancouver/ICMJE Style

Gunor ND, Gurbuz T, Yurci A. Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. Ulutas Med J. (2021), [cited March 29, 2021]; 7(1): 22-30. doi:10.5455/umj.20210305041537



Harvard Style

Gunor, N. D., Gurbuz, . T. & Yurci, . A. (2021) Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. Ulutas Med J, 7 (1), 22-30. doi:10.5455/umj.20210305041537



Turabian Style

Gunor, Nur Dokuzeylul, Tugba Gurbuz, and Arzu Yurci. 2021. Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. THE ULUTAS MEDICAL JOURNAL, 7 (1), 22-30. doi:10.5455/umj.20210305041537



Chicago Style

Gunor, Nur Dokuzeylul, Tugba Gurbuz, and Arzu Yurci. "Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?." THE ULUTAS MEDICAL JOURNAL 7 (2021), 22-30. doi:10.5455/umj.20210305041537



MLA (The Modern Language Association) Style

Gunor, Nur Dokuzeylul, Tugba Gurbuz, and Arzu Yurci. "Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?." THE ULUTAS MEDICAL JOURNAL 7.1 (2021), 22-30. Print. doi:10.5455/umj.20210305041537



APA (American Psychological Association) Style

Gunor, N. D., Gurbuz, . T. & Yurci, . A. (2021) Does Depot Analog Suppression Have Positive Effects on All Other Frozen-thawed Embryo Transfer Cycles in Addition to Endometriosis?. THE ULUTAS MEDICAL JOURNAL, 7 (1), 22-30. doi:10.5455/umj.20210305041537