E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency

Sinan Tufekci, Ozgur Kizilca, Ozge Yerlioglu.

Abstract
Introduction: Vitamin B12 (Vit-B12) levels between the mothers and their infants in a neonatology unit were investigated and the effectiveness of oral methylcobalamin treatment in neonatal Vit-B12 deficiency was evaluated.
Materials and Methods: Eighty patients born between July 2018 and April 2020 at 34–42 weeks of gestation and who were found to have Vit-B12 deficiency were included in this cross-sectional study. Oral methylcobalamin was given to 40 patients, and 40 patients were followed up. Vit-B12 level and blood gas were measured in the umbilical cord blood of the infants, and a complete blood count was performed on the first day. Vit-B12 levels of the mothers were assessed. Complete blood count and Vit-B12 level were measured on the postnatal 30th day in patients who were followed up without treatment and 5 days after treatment in patients who received oral methylcobalamin treatment for 1 month.
Results: In the treatment group, the mean umbilical cord Vit-B12 level was 155.5 (±29.1) pg/ml, and the mean Vit-B12 level of the mothers was 158.8 (±57.6) pg/ml. The mean follow-up Vit-B12 level was 801.8 (±394.7) pg/ml. In the untreated group, the mean umbilical cord Vit-B12 level was 159.3 (±34.1) pg/ml, and the mean Vit-B12 level in mothers was 146.2 (±49.7) pg/ml. The mean follow-up Vit-B12 level was 189.2 (±57.6) pg/ml.
Conclusion: There was a positive correlation between umbilical cord Vit-B12 and mothers' Vit-B12 levels. Oral methylcobalamin treatment was found to be effective and safe in Vit-B12 deficiency.

Key words: Maternal vitamin B12 deficiency, newborn vitamin B12 deficiency, oral methylcobalamin treatment, umbilical cord


 
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How to Cite this Article
Pubmed Style

Tufekci S, Kizilca O, Yerlioglu O. Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. Ulutas Med J. 2021; 7(1): 31-37. doi:10.5455/umj.20210222023948


Web Style

Tufekci S, Kizilca O, Yerlioglu O. Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. http://www.ulutasmedicaljournal.com/?mno=58231 [Access: March 29, 2021]. doi:10.5455/umj.20210222023948


AMA (American Medical Association) Style

Tufekci S, Kizilca O, Yerlioglu O. Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. Ulutas Med J. 2021; 7(1): 31-37. doi:10.5455/umj.20210222023948



Vancouver/ICMJE Style

Tufekci S, Kizilca O, Yerlioglu O. Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. Ulutas Med J. (2021), [cited March 29, 2021]; 7(1): 31-37. doi:10.5455/umj.20210222023948



Harvard Style

Tufekci, S., Kizilca, . O. & Yerlioglu, . O. (2021) Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. Ulutas Med J, 7 (1), 31-37. doi:10.5455/umj.20210222023948



Turabian Style

Tufekci, Sinan, Ozgur Kizilca, and Ozge Yerlioglu. 2021. Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. THE ULUTAS MEDICAL JOURNAL, 7 (1), 31-37. doi:10.5455/umj.20210222023948



Chicago Style

Tufekci, Sinan, Ozgur Kizilca, and Ozge Yerlioglu. "Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency." THE ULUTAS MEDICAL JOURNAL 7 (2021), 31-37. doi:10.5455/umj.20210222023948



MLA (The Modern Language Association) Style

Tufekci, Sinan, Ozgur Kizilca, and Ozge Yerlioglu. "Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency." THE ULUTAS MEDICAL JOURNAL 7.1 (2021), 31-37. Print. doi:10.5455/umj.20210222023948



APA (American Psychological Association) Style

Tufekci, S., Kizilca, . O. & Yerlioglu, . O. (2021) Oral Methylcobalamin Treatment Effectiveness of Newborn with Vitamin B12 Deficiency. THE ULUTAS MEDICAL JOURNAL, 7 (1), 31-37. doi:10.5455/umj.20210222023948