E-ISSN 2149-388X | ISSN 2149-0430
 

Original Article 


Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit

Hamza Cengiz, Kamil Yilmaz, Ayfer Gozu Pirinccioglu, Ahmet Kan.

Abstract
Introduction: Sepsis is one of the leading causes of mortality and morbidity in intensive care units. In this study, we aimed to investigate the etiological cause, focus of infection, culture sample results, and inflammatory markers among patients treated for sepsis at pediatric intensive care units (PICUs).
Materials and Methods: We retrospectively reviewed the medical records of 70 patients aged 1 month to 18 years who were treated for sepsis at PICU between January 2014 and May 2019.
Results: The median age of the patients was 37 months. The most common underlying etiology was respiratory failure (70%). The most common site of infection causing sepsis was the respiratory system (n:40, 57%). The most commonly isolated agents were Proteus mirabilis and Acinetobacter baumannii. Whereas C reactive protein (CRP) was normal at the time of the diagnosis of sepsis in 28.5% (n=20) of the patients, procalcitonin (PCT) was elevated in all of them. A comparison of the laboratory parameters in the first 24 hours after the diagnosis of sepsis and at the end of the treatment revealed a significant difference between White blood cell (WBC) count, neutrophil-lymphocyte ratio (NLR), the levels of C reactive protein (CRP) and Procalcitonin (p<0.05). In addition, positive correlations were detected between NLR, CRP and PCT (p=0.036, p=0.012/ r=0.251, r:0.299, respectively).
Conclusion: We believe that PCT, CRP, and NLR can be used as biomarkers for monitoring patients with sepsis.

Key words: CRP, NLR, PICU, procalcitonin, sepsis


 
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How to Cite this Article
Pubmed Style

Cengiz H, Yilmaz K, Pirinccioglu AG, Kan A. Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. Ulutas Med J. 2021; 7(2): 77-85. doi:10.5455/umj.20210504075319


Web Style

Cengiz H, Yilmaz K, Pirinccioglu AG, Kan A. Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. http://www.ulutasmedicaljournal.com/?mno=78740 [Access: June 24, 2021]. doi:10.5455/umj.20210504075319


AMA (American Medical Association) Style

Cengiz H, Yilmaz K, Pirinccioglu AG, Kan A. Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. Ulutas Med J. 2021; 7(2): 77-85. doi:10.5455/umj.20210504075319



Vancouver/ICMJE Style

Cengiz H, Yilmaz K, Pirinccioglu AG, Kan A. Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. Ulutas Med J. (2021), [cited June 24, 2021]; 7(2): 77-85. doi:10.5455/umj.20210504075319



Harvard Style

Cengiz, H., Yilmaz, . K., Pirinccioglu, . A. G. & Kan, . A. (2021) Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. Ulutas Med J, 7 (2), 77-85. doi:10.5455/umj.20210504075319



Turabian Style

Cengiz, Hamza, Kamil Yilmaz, Ayfer Gozu Pirinccioglu, and Ahmet Kan. 2021. Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. THE ULUTAS MEDICAL JOURNAL, 7 (2), 77-85. doi:10.5455/umj.20210504075319



Chicago Style

Cengiz, Hamza, Kamil Yilmaz, Ayfer Gozu Pirinccioglu, and Ahmet Kan. "Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit." THE ULUTAS MEDICAL JOURNAL 7 (2021), 77-85. doi:10.5455/umj.20210504075319



MLA (The Modern Language Association) Style

Cengiz, Hamza, Kamil Yilmaz, Ayfer Gozu Pirinccioglu, and Ahmet Kan. "Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit." THE ULUTAS MEDICAL JOURNAL 7.2 (2021), 77-85. Print. doi:10.5455/umj.20210504075319



APA (American Psychological Association) Style

Cengiz, H., Yilmaz, . K., Pirinccioglu, . A. G. & Kan, . A. (2021) Evaluation of Biomarkers in Patients with Sepsis Diagnosis in Pediatric Intensive Care Unit. THE ULUTAS MEDICAL JOURNAL, 7 (2), 77-85. doi:10.5455/umj.20210504075319