Abstract
Introduction: Diabetic foot (DF) is the leading risk factor for amputation. The lifetime risk of lower extremity amputation in DF people is at least 19%. As the life expectancy of diabetic patients increases due to advances in treatment methods, the incidence and prevalence of amputation increases. Therefore, better characterizing the frequency, clinical course, and risk factors of DF-related amputations will be beneficial in treatment.
Materials and Methods: A total of 523 patients who underwent amputation due to DF between 2012 and 2022 were included in this study. The history of dialysis treatment of the patients, the follow-up period, the survival time, the use of anticoagulants, above knee amputation, hyperbaric oxygen therapy (HbO), vacuum assisted closure therapy (VAC), peripheral arterial disease (PAD), and fourth generation antibiotic use were recorded. C-reactive protein (CRP), blood urea nitrogen (BUN), glycated hemoglobin (HbA1c), erythrocyte sedimentation rate (ESR), and creatinine levels were determined from the files. Grouped and compared according to dialysis treatment, 4th generation antibiotic use and above knee amputation.
Results: Follow-up period, survival time, above knee amputation, HbO, PAD and 4th generation antibiotic use were significantly different in the dialysis group. When compared according to the use of 4th generation antibiotic, follow-up period and PAD were significantly different. PAD and anticoagulant were significant in the above knee amputation group. Dialysis treatment has been found to shorten survival time.
Conclusions: Fourth generation antibiotic use and above knee amputation do not affect survival time. The survival time of patients receiving dialysis treatment decreases.

Key words: Diabetic foot; amputation; dialysis treatment; fourth-generation antibiotic; above knee amputation