Abstract
Introduction: In recent years, the incidence rates of many B-cell lymphomas have begun to decline in the United States, in contrast, incidence rates for T-cell lymphomas have continued to rise. T-cell lymphomas comprise multiple subtypes with different incidence rates and patterns that likely reflect their distinct etiologies. Incidence rates for lymphoid malignancies also vary by geography and there are some particular differences by subtypes. Human T-cell lymphotropic virus I (HTLV-1) which is endemic in Japan and the Caribbean, northeast of Iran, resulting in elevated rates of ATLs in these regions, but in non-endemic area such as North America Peripheral T cell lymphoma (PTCL) is the most common T cell lymphoma.
Conclusion: With multidisciplinary approaches to epidemiologic research, the major hurdles for uncovering T-cell lymphoma risk factors may finally be surmountable.