E-ISSN 2149-388X | ISSN 2149-0430
 

Original Research 


High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan.


Abstract
Introduction: Elevated galectin-3 (GAL-3) levels has been associated with decompensated heart failure (HF) which is a complex mechanical and neurohormonal syndrome. Many clinical and biochemical factors have been implicated in the pathophysiology of HF. In a group of patients who are referred to the emergency clinic for HF, GAL-3 levels and their association with various clinical and biochemical parameters were determined. GAL-3levels were measured with the VIDAS® automated enzyme-linked fluorescent assay (BioMérieux, France).
Method: Our study group consists of 70 patients (33 women and 37 men) and 25 healthy controls. All 70 patients had at least Class II or higher levels of HF according to NYHA criteria.
Results: GAL-3 was significantly higher in the patient's group (17.98 vs. 10.24 ng/mL; p<000,1). 53 patients had atherosclerotic heart disease, 14 patients had intracardiac cardioverter-defibrillator implantation (ICD), 37 atrial fibrillation and 25 patients had type 2 diabetes mellitus. Low levels of chloremia, low red cell width ( RDW), as a low blood count parameter low mean corpuscular hemoglobin concentration (MCHC) and higher age were associated with elevated levels of GAL-3.
Statistical analysis has shown that galectin-3 was significantly associated with hypochloremia (p=0.002), MCHC (p=0.002), RDW (p=0.009). Age, hyponatremia, and anemia are clinically slightly relevant indices of decompensated HF associated with high levels of GAL-3.
Conclusion: The measurement of GAL-3 may represent a new alternative biomarker in decision making for HF. Clinical parameters associated with GAL-3 may illuminate new pathophysiologic mechanisms in HF.

Key words: Galectin-3, Heart Failure, RDW, Hyponatremia, Anemia, MCHC


 
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How to Cite this Article
Pubmed Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. Ulutas Med J. 2016; 2(4): 159-165. doi:10.5455/umj.20161215092108


Web Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. https://www.ulutasmedicaljournal.com/?mno=227568 [Access: March 06, 2024]. doi:10.5455/umj.20161215092108


AMA (American Medical Association) Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. Ulutas Med J. 2016; 2(4): 159-165. doi:10.5455/umj.20161215092108



Vancouver/ICMJE Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. Ulutas Med J. (2016), [cited March 06, 2024]; 2(4): 159-165. doi:10.5455/umj.20161215092108



Harvard Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan (2016) High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. Ulutas Med J, 2 (4), 159-165. doi:10.5455/umj.20161215092108



Turabian Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. 2016. High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. THE ULUTAS MEDICAL JOURNAL, 2 (4), 159-165. doi:10.5455/umj.20161215092108



Chicago Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. "High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure." THE ULUTAS MEDICAL JOURNAL 2 (2016), 159-165. doi:10.5455/umj.20161215092108



MLA (The Modern Language Association) Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan. "High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure." THE ULUTAS MEDICAL JOURNAL 2.4 (2016), 159-165. Print. doi:10.5455/umj.20161215092108



APA (American Psychological Association) Style

Aysem Kaya, Evin Ademoglu, Zerrin Yigit, Sevim Purisa, Isil Uzunhasan (2016) High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure. THE ULUTAS MEDICAL JOURNAL, 2 (4), 159-165. doi:10.5455/umj.20161215092108