E-ISSN 2149-388X | ISSN 2149-0430
 

Review Article 


Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri.


Cited By:2

Abstract
Hepatocellular carcinoma is one of the most common malignant tumor and leading cause of death worldwide. Tumor genes, signals from tumor stroma, recruited inflammatory cells and hypoxia has been reported to switch on angiogenesis. Vascular endothelial growth factor is a pleiotropic factor that regulates cell proliferation, vascular permeability and plays an important role in tumor angiogenesis through its different angiogenic receptors. Multifunctional regulatory cytokine transforming growth factor-β also controls cell proliferation, differentiation, extracellular matrix production and survival/or apoptosis of many types cells. By raising level of epithelial–mesenchymal transition, transforming growth factor-β creates a favourable microenvironment for tumor cell growth. Depending upon the stage of cancer progression it can either initiate tumor development, progression and metastasis or can act as a tumor suppressor. In the present review, an attempt has been made to comprehensively define the role of Vascular Endothelial Growth Factor and transforming growth factor-β in the development and progression of hepatocellular carcinoma.

Key words: Hepatocellular carcinoma; VEGF; TGF-β; angiogenesis; cancer


 
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How to Cite this Article
Pubmed Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309


Web Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. https://www.ulutasmedicaljournal.com/?mno=268878 [Access: March 06, 2024]. doi:10.5455/umj.20170608022309


AMA (American Medical Association) Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309



Vancouver/ICMJE Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. (2017), [cited March 06, 2024]; 3(2): 25-31. doi:10.5455/umj.20170608022309



Harvard Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J, 3 (2), 25-31. doi:10.5455/umj.20170608022309



Turabian Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. 2017. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309



Chicago Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3 (2017), 25-31. doi:10.5455/umj.20170608022309



MLA (The Modern Language Association) Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3.2 (2017), 25-31. Print. doi:10.5455/umj.20170608022309



APA (American Psychological Association) Style

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309