Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran

Saeedeh TarvijEslami; Hosain Nasirian; Arezoo Sadat Razavi; Hamid Zaferani Arani; Mahshid Dareh; Poorya Bikarannejad; Yasamin Zivari; Maryam Sadat Motevalli; Seyed Amirhossein Ahmadi; Elnaz Babakhani

doi:10.5455/umj.20190502070257

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Ulutas Med J. 2019; 5(3): 175-183

doi: 10.5455/umj.20190502070257

Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran

Saeedeh Tarvijeslami, Hosain Nasirian, Arezoo Sadat Razavi, Hamid Zaferani Arani, Mahshid Dareh, Poorya Bikarannejad, Yasamin Zivari, Maryam Sadat Motevalli, Seyed Amirhossein Ahmadi, Elnaz Babakhani.

Abstract
Background: The promotion of breastfeeding is a simple and efficient strategy in reducing morbidity and mortality among newborns worldwide. Domperidone is a blocker of dopamine receptors, which causes prolactin release. We aimed to determine the efficacy of Domperidone on the amount of breast milk secretion among mothers with low-milk-production.
Materials and Methods: This interventional study was performed on 16 consecutive low-milk-producing women who were attending to Azad University Hospitals during 2013-2014. Eligible mothers received Domperidone at a dose of 30 mg orally/day (10 mg tablet three times daily) for a week. Breast-milk volume, as well as the serum levels of prolactin, were determined before and after the intervention. Also, any adverse drug reactions were recorded.
Results: The mean breast milk volume was 173.7±47.7 and 326.8±26.1 ml before and after the intervention, respectively. Also, administered of Domperidone cloud significantly increase of %53.1 (p<0.001) in daily milk production. Also, the mean serum prolactin level was 161.1±19.1 and 254±25.5 ng/ml, before and after medications, respectively, which showed a significant increase of %63.46 (p=0.0001).
Conclusion: Domperidone increases the volume of breast milk production among nursing mothers. There was no drug-related side effect for mothers and infants.

Key words: Breast Feeding, Domperidone, Efficacy, Side Effects

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How to Cite this Article

Pubmed Style

Tarvijeslami S, Nasirian H, Razavi AS, Arani HZ, Dareh M, Bikarannejad P, Zivari Y, Motevalli MS, Ahmadi SA, Babakhani E. Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. Ulutas Med J. 2019; 5(3): 175-183. doi:10.5455/umj.20190502070257

Web Style

Tarvijeslami S, Nasirian H, Razavi AS, Arani HZ, Dareh M, Bikarannejad P, Zivari Y, Motevalli MS, Ahmadi SA, Babakhani E. Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. https://www.ulutasmedicaljournal.com/?mno=46759 [Access: March 15, 2025]. doi:10.5455/umj.20190502070257

AMA (American Medical Association) Style

Tarvijeslami S, Nasirian H, Razavi AS, Arani HZ, Dareh M, Bikarannejad P, Zivari Y, Motevalli MS, Ahmadi SA, Babakhani E. Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. Ulutas Med J. 2019; 5(3): 175-183. doi:10.5455/umj.20190502070257

Vancouver/ICMJE Style

Tarvijeslami S, Nasirian H, Razavi AS, Arani HZ, Dareh M, Bikarannejad P, Zivari Y, Motevalli MS, Ahmadi SA, Babakhani E. Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. Ulutas Med J. (2019), [cited March 15, 2025]; 5(3): 175-183. doi:10.5455/umj.20190502070257

Harvard Style

Tarvijeslami, S., Nasirian, . H., Razavi, . A. S., Arani, . H. Z., Dareh, . M., Bikarannejad, . P., Zivari, . Y., Motevalli, . M. S., Ahmadi, . S. A. & Babakhani, . E. (2019) Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. Ulutas Med J, 5 (3), 175-183. doi:10.5455/umj.20190502070257

Turabian Style

Tarvijeslami, Saeedeh, Hosain Nasirian, Arezoo Sadat Razavi, Hamid Zaferani Arani, Mahshid Dareh, Poorya Bikarannejad, Yasamin Zivari, Maryam Sadat Motevalli, Seyed Amirhossein Ahmadi, and Elnaz Babakhani. 2019. Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. THE ULUTAS MEDICAL JOURNAL, 5 (3), 175-183. doi:10.5455/umj.20190502070257

Chicago Style

Tarvijeslami, Saeedeh, Hosain Nasirian, Arezoo Sadat Razavi, Hamid Zaferani Arani, Mahshid Dareh, Poorya Bikarannejad, Yasamin Zivari, Maryam Sadat Motevalli, Seyed Amirhossein Ahmadi, and Elnaz Babakhani. "Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran." THE ULUTAS MEDICAL JOURNAL 5 (2019), 175-183. doi:10.5455/umj.20190502070257

MLA (The Modern Language Association) Style

Tarvijeslami, Saeedeh, Hosain Nasirian, Arezoo Sadat Razavi, Hamid Zaferani Arani, Mahshid Dareh, Poorya Bikarannejad, Yasamin Zivari, Maryam Sadat Motevalli, Seyed Amirhossein Ahmadi, and Elnaz Babakhani. "Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran." THE ULUTAS MEDICAL JOURNAL 5.3 (2019), 175-183. Print. doi:10.5455/umj.20190502070257

APA (American Psychological Association) Style

Tarvijeslami, S., Nasirian, . H., Razavi, . A. S., Arani, . H. Z., Dareh, . M., Bikarannejad, . P., Zivari, . Y., Motevalli, . M. S., Ahmadi, . S. A. & Babakhani, . E. (2019) Effect of Domperidone on Lactation in Low Milk Supply Women in Tehran, Iran. THE ULUTAS MEDICAL JOURNAL, 5 (3), 175-183. doi:10.5455/umj.20190502070257

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