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2025, Vol: 11, Issue: 1
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Review Article 


Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals

Roshni Rajpoot, Raj Kumar Koiri.


Abstract
Eutrophication and climate change have raised obnoxious cyanobacterial blooms, which have become a global public health problem. The most dangerous cyanotoxin found in water bodies is microcystin (MC), a byproduct of cyanobacterial metabolism. Several studies suggest that in addition to the liver, the heart may be another target organ for MCs poisoning. Recent research indicates a clear link between MC exposure and cardiotoxicity, posing a risk to human cardiovascular health. The cardiovascular system, which includes all tissues, cells, blood, and vascular tissues of the heart, can be unswervingly affected by MCs, resulting in abnormal cardiovascular system structure and/or function. This review concludes that MC cardiotoxicity may be linked to protein phosphatase suppression and the contractile unit, generation of contractile force, the role of intercellular junction proteins, and the role of the angiotensin signaling pathway in cardiomyocytes.

Key words: Cyanotoxin; Microcystin-LR; Toxicity; Heart; OATP; Intercellular junction protein


 
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How to Cite this Article
Pubmed Style

Rajpoot R, Koiri RK. Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. Ulutas Med J. 2023; 9(2): 92-105. doi:10.5455/umj.20221222071638

Web Style

Rajpoot R, Koiri RK. Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. https://www.ulutasmedicaljournal.com/?mno=133517 [Access: March 15, 2025]. doi:10.5455/umj.20221222071638

AMA (American Medical Association) Style

Rajpoot R, Koiri RK. Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. Ulutas Med J. 2023; 9(2): 92-105. doi:10.5455/umj.20221222071638


Vancouver/ICMJE Style

Rajpoot R, Koiri RK. Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. Ulutas Med J. (2023), [cited March 15, 2025]; 9(2): 92-105. doi:10.5455/umj.20221222071638


Harvard Style

Rajpoot, R. & Koiri, . R. K. (2023) Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. Ulutas Med J, 9 (2), 92-105. doi:10.5455/umj.20221222071638


Turabian Style

Rajpoot, Roshni, and Raj Kumar Koiri. 2023. Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. THE ULUTAS MEDICAL JOURNAL, 9 (2), 92-105. doi:10.5455/umj.20221222071638


Chicago Style

Rajpoot, Roshni, and Raj Kumar Koiri. "Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals." THE ULUTAS MEDICAL JOURNAL 9 (2023), 92-105. doi:10.5455/umj.20221222071638


MLA (The Modern Language Association) Style

Rajpoot, Roshni, and Raj Kumar Koiri. "Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals." THE ULUTAS MEDICAL JOURNAL 9.2 (2023), 92-105. Print. doi:10.5455/umj.20221222071638


APA (American Psychological Association) Style

Rajpoot, R. & Koiri, . R. K. (2023) Profoundal Effects of Microcystin-LR Induced Cardiotoxicity in Mammals. THE ULUTAS MEDICAL JOURNAL, 9 (2), 92-105. doi:10.5455/umj.20221222071638


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