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Online Published: 07 May 2015
 


Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed

Chinwe Ewenighi, Uchechukwu Dimkpa, Joel Onyeanusi, Linus Onoh, Gladys Onoh, Uchechukwu Ezeugwu.


Cited By:50

Abstract
Aim: Hypoglyceamic effect of Garcinia kola (GK) was evaluated in alloxan induced diabetic rats.
Method: Eighteen male wistar albino rats of weights between 158-172g were divided into three groups A- C. Group A was given distilled water (D/W) throughout the experiment; diabetes was induced in group B and C. Group B was given d/w but not GK while group C was treated with GK extract for 21 days. Fasting blood samples were collected at baseline, 24 hours, 7th, 14th and 21st day for blood glucose evaluation.
Results: Mean fasting blood glucose (FBG) level was significantly higher (P<0.001) after 24 hours diabetes induction with alloxan in groups B and C rats compared to the baseline. Group B showed geometric increase in FBG level and decrease in body weight from 24 hours after diabetes induction to the 21st day of study duration. Group C rats had significantly lower (P<0.001) mean FBG level than Group B rats. Significant difference in body weight was observed among the 3 groups throughout the study periods but for baseline.
Conclusion: Treatment of alloxan induced diabetic rats with GK extract lowers blood glucose level and restores weight loss.

Key words: Garcinia kola, alloxan, glucose, diabetes mellitus, hypoglyceamia, hyperglyceamia


 
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How to Cite this Article
Pubmed Style

Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. Ulutas Med J. 2015; 1(2): 26-30. doi:10.5455/umj.20150507042420

Web Style

Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. https://www.ulutasmedicaljournal.com/?mno=187367 [Access: March 15, 2025]. doi:10.5455/umj.20150507042420

AMA (American Medical Association) Style

Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. Ulutas Med J. 2015; 1(2): 26-30. doi:10.5455/umj.20150507042420


Vancouver/ICMJE Style

Ewenighi C, Dimkpa U, Onyeanusi J, Onoh L, Onoh G, Ezeugwu U. Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. Ulutas Med J. (2015), [cited March 15, 2025]; 1(2): 26-30. doi:10.5455/umj.20150507042420


Harvard Style

Ewenighi, C., Dimkpa, . U., Onyeanusi, . J., Onoh, . L., Onoh, . G. & Ezeugwu, . U. (2015) Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. Ulutas Med J, 1 (2), 26-30. doi:10.5455/umj.20150507042420


Turabian Style

Ewenighi, Chinwe, Uchechukwu Dimkpa, Joel Onyeanusi, Linus Onoh, Gladys Onoh, and Uchechukwu Ezeugwu. 2015. Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. THE ULUTAS MEDICAL JOURNAL, 1 (2), 26-30. doi:10.5455/umj.20150507042420


Chicago Style

Ewenighi, Chinwe, Uchechukwu Dimkpa, Joel Onyeanusi, Linus Onoh, Gladys Onoh, and Uchechukwu Ezeugwu. "Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed." THE ULUTAS MEDICAL JOURNAL 1 (2015), 26-30. doi:10.5455/umj.20150507042420


MLA (The Modern Language Association) Style

Ewenighi, Chinwe, Uchechukwu Dimkpa, Joel Onyeanusi, Linus Onoh, Gladys Onoh, and Uchechukwu Ezeugwu. "Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed." THE ULUTAS MEDICAL JOURNAL 1.2 (2015), 26-30. Print. doi:10.5455/umj.20150507042420


APA (American Psychological Association) Style

Ewenighi, C., Dimkpa, . U., Onyeanusi, . J., Onoh, . L., Onoh, . G. & Ezeugwu, . U. (2015) Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed. THE ULUTAS MEDICAL JOURNAL, 1 (2), 26-30. doi:10.5455/umj.20150507042420


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