E-ISSN 2149-388X | ISSN 2149-0430
 
2025, Vol: 11, Issue: 1
11 / 1Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Cover Letter
License Agreement
Title Page

Review Article 


Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma

Saurabh Kumar Chhonker, Divya Rawat, Raj Kumar Koiri.


Cited By:2

Abstract
Hepatocellular carcinoma is one of the most common malignant tumor and leading cause of death worldwide. Tumor genes, signals from tumor stroma, recruited inflammatory cells and hypoxia has been reported to switch on angiogenesis. Vascular endothelial growth factor is a pleiotropic factor that regulates cell proliferation, vascular permeability and plays an important role in tumor angiogenesis through its different angiogenic receptors. Multifunctional regulatory cytokine transforming growth factor-β also controls cell proliferation, differentiation, extracellular matrix production and survival/or apoptosis of many types cells. By raising level of epithelial–mesenchymal transition, transforming growth factor-β creates a favourable microenvironment for tumor cell growth. Depending upon the stage of cancer progression it can either initiate tumor development, progression and metastasis or can act as a tumor suppressor. In the present review, an attempt has been made to comprehensively define the role of Vascular Endothelial Growth Factor and transforming growth factor-β in the development and progression of hepatocellular carcinoma.

Key words: Hepatocellular carcinoma; VEGF; TGF-β; angiogenesis; cancer


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Saurabh Kumar Chhonker
Articles by Divya Rawat
Articles by Raj Kumar Koiri
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309

Web Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. https://www.ulutasmedicaljournal.com/?mno=268878 [Access: March 15, 2025]. doi:10.5455/umj.20170608022309

AMA (American Medical Association) Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. 2017; 3(2): 25-31. doi:10.5455/umj.20170608022309


Vancouver/ICMJE Style

Chhonker SK, Rawat D, Koiri RK. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J. (2017), [cited March 15, 2025]; 3(2): 25-31. doi:10.5455/umj.20170608022309


Harvard Style

Chhonker, S. K., Rawat, . D. & Koiri, . R. K. (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. Ulutas Med J, 3 (2), 25-31. doi:10.5455/umj.20170608022309


Turabian Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. 2017. Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309


Chicago Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3 (2017), 25-31. doi:10.5455/umj.20170608022309


MLA (The Modern Language Association) Style

Chhonker, Saurabh Kumar, Divya Rawat, and Raj Kumar Koiri. "Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma." THE ULUTAS MEDICAL JOURNAL 3.2 (2017), 25-31. Print. doi:10.5455/umj.20170608022309


APA (American Psychological Association) Style

Chhonker, S. K., Rawat, . D. & Koiri, . R. K. (2017) Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β in Hepatocellular Carcinoma. THE ULUTAS MEDICAL JOURNAL, 3 (2), 25-31. doi:10.5455/umj.20170608022309


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About THE ULUTAS MEDICAL JOURNAL

The Ulutas Medical Journal (UMJ) is a 3 monthly (quarterly), open access, double-blind peer-reviewed, an international journal. Writing a research pap ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Journal Owner
HAYRİYE ZEHRA ULUTAŞ
Phone: +90 (532) 165 96 39​
E-mail: zehrakenanoglu@hotmail.com​
Address: Alaattin Mah. 30. Ada sok. D11 Blok
No:4 Gungor Uydukent Sitesi  Antakya/HATAY

Editor-In-Chief
KEMAL TURKER ULUTAS, MD, Assc. Prof.
Phone: + 90 (555) 491 35 59​
E-mail: drkemalturker@gmail.com
Address: Alaattin Mah. 30. Ada sok. D11 Blok
No:4 Gungor Uydukent Sitesi  Antakya/HATAY

Publisher Information
SCOPEMED Publishing Co. - TURKEY​
E-mail: scopemed@scopemed.org
Web: https://www.scopemed.com/

 

We welcome your submissions, suggestions, comments, or questions. To reach us, please use one of the methods provided on this page or Email us at ulutasmedicaljournal@gmail.com​

We will respond within 48 to 72 hours.