Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis

Stefan Kovachev; Rossitza Vatcheva-Dobrevska

doi:10.5455/umj.20160210060327

Original Research

Ulutas Med J. 2016; 2(1): 20-26

doi: 10.5455/umj.20160210060327

Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis

Stefan Kovachev, Rossitza Vatcheva-Dobrevska.

Abstract
Introduction: The objective of this study was to establish the efficacy of local probiotic monotherapy for the treatment of bacterial vaginosis.
Method: A total of 141 women with bacterial vaginosis, randomized into two groups, were examined. In the first group, 85 women were treated with local probiotic medicine (QD for 10 days) containing Lactobacillus casei var rhamnosus Döderlein (Lcr35®). In the second group, 56 patients received the same local probiotic treatment as those in the first group, in addition to treatment with an oral administration of metronidazol (500 mg tablet BID for 7 days). The efficacy of the monotherapeutic scheme was evaluated by comparing the number of clinical complaints and the results of clinical examinations and microbiological tests in the two groups.
Results: One month after the probiotic monotherapy in the first group, the clinical efficacy was 47.1% and the microbiological efficacy was 41.1%. The combined treatment in the second group was more efficacious (clinical efficacy: 89.3%; microbiological efficacy: 76.7%).
Conclusions: Thus, our results indicate that local probiotic monotherapy is less effective than combined metronidazole/probiotic scheme for the treatment of bacterial vaginosis.

Key words: Lactobacilli, monotherapy, probiotic, vaginal flora

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REFERENCES

1. Chimura T, Funayama T, Murayama K, Numazaki M. Ecological treatment of bacterial vaginosis. Jpn J Antibiot 1995; 48: 432-436. [Pubmed]

2. Fredricsson B, Englund K, Weintraub L, Olund A, Nord CE. Bacterial vaginosis is not a simple ecological disorder. Gynecol Obstet Invest 1989; 28:156-160. [DOI via Crossref] [Pubmed]

3. Hemalatha R, Mastromarino P, Ramalaxmi BA, Balakrishna NV, Sesikeran B. Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines: a randomized, double-blind study. Eur J Clin Microbiol Infect Dis 2012; 31(11):3097-105. [DOI via Crossref] [Pubmed]

4. Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach D, Holmes KK. Non-specific vaginitis: diagnostic and microbial and epidemiological associations. Am J Med 1983;74:14-22. [DOI via Crossref]

5. Nugent RP, Krohn MA, Hillier S. Reliability of diagnosing bacterial vaginosis is improved by standardized method of Gram stain interpretation. J Clin Microbiol 1991;29:297-301. [Pubmed] [PMC Free Fulltext]

6. Ison CA, Hay PE. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics. Sex Transm Infect 2002; 78: 413-415. [DOI via Crossref] [PMC Free Fulltext]

7. Hallen A, Jarstrand C, Pahlson C. Treatment of bacterial vaginosis with lactobacilli. Sex Transm Dis 1992;19:146-148. [DOI via Crossref] [Pubmed]

8. Rossi A, Rossi T, Bertini M, Caccia G. The use of Lactobacillus rhamnosus in the therapy of bacterial vaginosis. Evaluation of clinical efficacy in a population of 40 women treated for 24 months. Arch Gynecol Obstet 2010; 281(6):1065-9. [DOI via Crossref] [Pubmed]

9. Mastromarino P, Macchia S, Meggiorini L, Trinchieri V, Mosca L, Perluidgi M, Midulla C. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 2009; 15(1): 67-74. [DOI via Crossref] [Pubmed]

10. Sigridov I, Ivanov S, Batashki I. Preliminary results of Lactofem trial-first impressions. Akush Ginekol (Sofiia) 2007; 46 Suppl 2: 29-32.

11. Eriksson K, Carlsson B, Forsum U, Larsson PG. A doubleblind treatment study of bacterial vaginosis with normal vaginal lactobacilli after an open treatment with vaginal clindamycin ovules. Acta Derm Venereol 2005; 85: 42-46. [DOI via Crossref] [Pubmed]

How to Cite this Article

Pubmed Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. Ulutas Med J. 2016; 2(1): 20-26. doi:10.5455/umj.20160210060327

Web Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. https://www.ulutasmedicaljournal.com/?mno=216967 [Access: March 25, 2023]. doi:10.5455/umj.20160210060327

AMA (American Medical Association) Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. Ulutas Med J. 2016; 2(1): 20-26. doi:10.5455/umj.20160210060327

Vancouver/ICMJE Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. Ulutas Med J. (2016), [cited March 25, 2023]; 2(1): 20-26. doi:10.5455/umj.20160210060327

Harvard Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska (2016) Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. Ulutas Med J, 2 (1), 20-26. doi:10.5455/umj.20160210060327

Turabian Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. 2016. Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. THE ULUTAS MEDICAL JOURNAL, 2 (1), 20-26. doi:10.5455/umj.20160210060327

Chicago Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska. "Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis." THE ULUTAS MEDICAL JOURNAL 2 (2016), 20-26. doi:10.5455/umj.20160210060327

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Stefan Kovachev, Rossitza Vatcheva-Dobrevska (2016) Efficacy of Local Lactobacillus Casei Var Rhamnosus Döderlein Monotherapy for Bacterial Vaginosis. THE ULUTAS MEDICAL JOURNAL, 2 (1), 20-26. doi:10.5455/umj.20160210060327



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