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Meta-Analysis 


Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis

Kun-yu Wu, Chien-ming Chao, Guang-mao Lee.


Abstract
This meta-analysis investigated whether the clinical efficacy of doripenem is comparable to that of alternative antibiotics for treating hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). The PubMed, Web of Science, Cochrane Library, Ovid MEDLINE, and EBSCO databases were searched for literature published before October 20, 2021. Clinical studies comparing the efficacy of doripenem with that of other antibiotics in HAP/VAP treatment were included. Primary outcomes included all-cause mortality at 28 to 30 days, whereas the secondary outcome was the clinical cure rate. In total, 5 clinical studies were included in this meta-analysis. All-cause mortality did not differ significantly between doripenem and the comparators. For VAP alone, no statistical differences were observed between doripenem and the comparators. For Pseudomonas aeruginosa-related pneumonia, mortality did not differ between doripenem and the comparators. The clinical cure rates were 60.7% and 57.3% for doripenem and the comparators, respectively; a similar trend was observed in the subgroup analysis for VAP. For HAP/VAP due to P. aeruginosa, the clinical cure rates for doripenem and the comparators did not differ. Doripenem was comparable to other antibiotics in the treatment of HAP and VAP.

Key words: Doripenem, hospital-acquired pneumonia, mortality, Pseudomonas aeruginosa, ventilator-associated pneumonia


 
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How to Cite this Article
Pubmed Style

Wu K, Chao C, Lee G. Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. Ulutas Med J. 2022; 8(3): 110-117. doi:10.5455/umj.20220513031721

Web Style

Wu K, Chao C, Lee G. Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. https://www.ulutasmedicaljournal.com/?mno=38410 [Access: March 15, 2025]. doi:10.5455/umj.20220513031721

AMA (American Medical Association) Style

Wu K, Chao C, Lee G. Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. Ulutas Med J. 2022; 8(3): 110-117. doi:10.5455/umj.20220513031721


Vancouver/ICMJE Style

Wu K, Chao C, Lee G. Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. Ulutas Med J. (2022), [cited March 15, 2025]; 8(3): 110-117. doi:10.5455/umj.20220513031721


Harvard Style

Wu, K., Chao, . C. & Lee, . G. (2022) Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. Ulutas Med J, 8 (3), 110-117. doi:10.5455/umj.20220513031721


Turabian Style

Wu, Kun-yu, Chien-ming Chao, and Guang-mao Lee. 2022. Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. THE ULUTAS MEDICAL JOURNAL, 8 (3), 110-117. doi:10.5455/umj.20220513031721


Chicago Style

Wu, Kun-yu, Chien-ming Chao, and Guang-mao Lee. "Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis." THE ULUTAS MEDICAL JOURNAL 8 (2022), 110-117. doi:10.5455/umj.20220513031721


MLA (The Modern Language Association) Style

Wu, Kun-yu, Chien-ming Chao, and Guang-mao Lee. "Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis." THE ULUTAS MEDICAL JOURNAL 8.3 (2022), 110-117. Print. doi:10.5455/umj.20220513031721


APA (American Psychological Association) Style

Wu, K., Chao, . C. & Lee, . G. (2022) Clinical Efficacy of Doripenem in Treating Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis. THE ULUTAS MEDICAL JOURNAL, 8 (3), 110-117. doi:10.5455/umj.20220513031721


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