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Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants

Okwute Michael Ochayi, Bond Anyaehie, Eghosa Iyare, Ngabea Murtala.


Abstract
Introduction: Oxidative stress has been a hallmark in cognitive disorders; there is a need to mitigate it and a suitable model for cognitive assessment in rodents. This study investigates the effects of Vitamin E and Selenium yeast on the cognitive performance of pregnant dams using percentage alternation and discrimination index determinants.
Materials and Methods: Thirty-five Wistar rats were used for this study and grouped into seven (n=5); group 1 (non-pregnant), group 2 (pregnant), group 3 (pregnant + received vitamin E; 100 mg/kg/day) group 4 (pregnant + received selenium-yeast; 0.4 mg/kg/day), group 5 (pregnant + received yeast; 50 mg/kg/day) group 6 (pregnant + received selenium; 0.25 mg/kg/day) and group 7 (pregnant + received vitamin E; 100 mg/kg/day + selenium-yeast; 0.4 mg/kg/day). Discrimination index was evaluated using novel object recognition, apparatus, while percentage alternation was evaluated using Y-maze on day 19.
Results: Percentage alternation increased in group 1 and antioxidants treated groups respectively compared to group 2 (p˂0.05). Discrimination index significantly increased in group 1 and antioxidants treated groups compared to group 2 (p˂0.05).
Conclusion: The percentage alternation and discrimination index show promising results in the cognitive assessment of pregnant dams. Antioxidant molecules such as vitamin E and selenium-yeast potentiate the indices of cognitive improvement.

Key words: Pregnant dams, discrimination index, percentage alternation, vitamin E, selenium-yeast


 
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How to Cite this Article
Pubmed Style

Ochayi OM, Anyaehie B, Iyare E, Murtala N. Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. Ulutas Med J. 2022; 8(3): 86-92. doi:10.5455/umj.20220526102156

Web Style

Ochayi OM, Anyaehie B, Iyare E, Murtala N. Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. https://www.ulutasmedicaljournal.com/?mno=48894 [Access: March 15, 2025]. doi:10.5455/umj.20220526102156

AMA (American Medical Association) Style

Ochayi OM, Anyaehie B, Iyare E, Murtala N. Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. Ulutas Med J. 2022; 8(3): 86-92. doi:10.5455/umj.20220526102156


Vancouver/ICMJE Style

Ochayi OM, Anyaehie B, Iyare E, Murtala N. Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. Ulutas Med J. (2022), [cited March 15, 2025]; 8(3): 86-92. doi:10.5455/umj.20220526102156


Harvard Style

Ochayi, O. M., Anyaehie, . B., Iyare, . E. & Murtala, . N. (2022) Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. Ulutas Med J, 8 (3), 86-92. doi:10.5455/umj.20220526102156


Turabian Style

Ochayi, Okwute Michael, Bond Anyaehie, Eghosa Iyare, and Ngabea Murtala. 2022. Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. THE ULUTAS MEDICAL JOURNAL, 8 (3), 86-92. doi:10.5455/umj.20220526102156


Chicago Style

Ochayi, Okwute Michael, Bond Anyaehie, Eghosa Iyare, and Ngabea Murtala. "Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants." THE ULUTAS MEDICAL JOURNAL 8 (2022), 86-92. doi:10.5455/umj.20220526102156


MLA (The Modern Language Association) Style

Ochayi, Okwute Michael, Bond Anyaehie, Eghosa Iyare, and Ngabea Murtala. "Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants." THE ULUTAS MEDICAL JOURNAL 8.3 (2022), 86-92. Print. doi:10.5455/umj.20220526102156


APA (American Psychological Association) Style

Ochayi, O. M., Anyaehie, . B., Iyare, . E. & Murtala, . N. (2022) Effects of Vitamin E and Selenium-yeast on Cognitive Performance in Pregnant Dams Using Percentage Alternation and Discrimination Index Determinants. THE ULUTAS MEDICAL JOURNAL, 8 (3), 86-92. doi:10.5455/umj.20220526102156


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